Worldwide study of breast cancer uncovers 72 new warning flags

Breast cancer

The World Health Organisation suggests breast cancer as one of the leading causes of mortality in women, especially in developing countries where most cases are detected in the later stages.

"As well as identifying new genetic variants, we have also confirmed many that we had previously suspected". Seven of the mutations found lead to a type of breast cancer that doesn't respond to traditional hormonal therapies, like tamoxifen.

"So, if a woman is a carrier of five variations, each of which increases the risk of breast cancer of 20 %, this risk becomes substantial since it is 2.5 times bigger than (1,25)", says Jacques Simard Centre de recherche du CHU de Québec-Université Laval, who is one of four principal investigators of the study that is the subject of two publications in Nature and Nature Genetics. If their theory is proven, it may explain why the majority of breast cancers have no genetic ties.

By comparing the genes of those diagnosed with the condition with those who had no history of breast cancer, the researchers were able to identify 65 variations of genes that contributed to the disease's development. These new genetic variations, we will probably answer, " stresses Dr. Jocelyne Chiquette, clinician at the Centre for breast diseases at Quebec, which is one of the authors of the study. "There's been a lot of research trying to figure out what that something else is". Just as it was true in 1985, it remains true today that mammography is the very best tool we have in the fight against breast cancer.

However, not all cancer cells carry this receptor - these are known as oestrogen-receptor negative.




I would advise readers to limit alcohol consumption to one drink per week, indulge in regular physical activities and exercise and control weight. Now, we have access to more accurate mammograms, such as the Genius 3D Mammography exam, that detects more invasive cancers, reduces false positives and is clinically proven as superior for women of all ages - even those with dense breasts compared to traditional 2D mammography.

"I had genetic testing and I was negative for all the genetic testing", Moeller said.

Professor Jacques Simard, from Laval University in Quebec city, Canada, another member of the worldwide team, said: 'Using data from genomic studies, combined with information on other known risk factors, will allow better breast cancer risk assessment, therefore helping to identify a small but meaningful proportion of women at high risk of breast cancer.

"Some of the variations are protective, others increase the risk".

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